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Following a Week 9 slate where NFL favorites went 14-1 straight-up, teams could see a pendulum swing toward more upsets in Week 10. CBS Sports Headlines highlights five favorites currently sitting on upset alert across the upcoming weekend matchups.
Washington Commanders at New York Giants
The Washington Commanders face the New York Giants at MetLife Stadium on Thursday night with a +2.5 underdog line. New York quarterback J.J. McCarthy is expected to play despite dealing with a hip pointer injury after taking five sacks and throwing for 127 yards against Philadelphia. Washington’s defense has allowed just 15.0 points per game over its last two outings, while quarterback Jayden Daniels holds a 3-0-1 career record against the division rival without throwing an interception this season.
New England Patriots at Detroit Lions
The New England Patriots travel to Munich, Germany, to face the Detroit Lions on Sunday morning as +2.5 underdogs. New England looks to rebound from a home loss to Green Bay, though turnovers have plagued 19.4% of their drives this season. However, Detroit’s defense has generated only eight turnovers, tied for the fourth-fewest in the NFL, which could provide relief for the Patriots. Meanwhile, Lions quarterback Jared Goff has seen his numbers dip during their winning streak, dropping from 297.0 passing yards per game and 12 touchdowns with zero interceptions over the first five weeks to 216.3 yards and a 3-2 TD-to-INT ratio recently.
Minnesota Vikings at Green Bay Packers
The Minnesota Vikings hit the road as +3.5 underdogs against the Green Bay Packers at Lambeau Field following a Monday night matchup. Minnesota acquired Kirk Cousins from the Raiders prior to the trade deadline to boost an offense that ranked 31st in passing yards per game and tied for the fewest offensive touchdowns. The Vikings defense will attempt to contain Green Bay’s passing attack without running back Josh Jacobs available for the Packers due to a broken finger. Green Bay also holds a 1-5 record in its last six games against division opponents.
Carolina Panthers at New Orleans Saints
The Carolina Panthers are +2.5 underdogs visiting the New Orleans Saints at Caesars Superdome on Sunday afternoon. Carolina quarterback Bryce Young averaged 216 passing yards with five touchdowns and four interceptions during a three-game losing skid against tough defenses like Tampa Bay, Green Bay, and Denver. New Orleans presents a weaker secondary that has allowed 7.3 yards per attempt and a 99.5 passer rating this season. The Saints have also struggled at home in 2026, posting a 1-4 record at the Superdome and failing to cover across five games.
Pittsburgh Steelers at Cincinnati Bengals
The Pittsburgh Steelers head to Paycor Stadium as +3.5 underdogs to face the Cincinnati Bengals on Sunday night. Cincinnati returns from an international game in Madrid while facing a massive rest disadvantage against a Pittsburgh squad coming off its Week 9 bye. Joe Burrow has led the Bengals on a four-game winning streak averaging over 35 points per game against the Dolphins, Ravens without Lamar Jackson, Titans, and Falcons. The Steelers defense provides a much stiffer test, ranking among the league leaders by allowing just 18.0 points per game and a 5.0 yards-per-play average, backed by a 6-0 record and cover rate coming off the bye week since 2020.
