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NFL Week 10 features major storylines under center, with rookies Fernando Mendoza and Carson Beck along with second-year quarterback Kyle McCord all set to make their first career starts on Sunday. The post-trade deadline landscape also brings notable changes, as Kirk Cousins returns to Minnesota and Jacoby Brissett steps in for the Baltimore Ravens following Lamar Jackson’s injury, creating new challenges for bettors across the league.
Pittsburgh Steelers at Cincinnati Bengals
The red-hot Cincinnati Bengals enter Week 10 on a four-legged winning streak averaging over 35 points per game under MVP-level quarterback Joe Burrow, who has tallied 18 total touchdowns during this stretch. However, CBS Sports highlights that their recent victories came against the Dolphins, a Lamar Jackson-less Ravens squad, the Titans, and the Falcons. Meanwhile, the Pittsburgh Steelers defense ranks among the league’s best, allowing just 18.0 points per game and boasting the fifth-lowest yards-per-play average at 5.0.
Beyond the defensive matchup, a significant schedule quirk favors Pittsburgh, who previously defeated Cincinnati in Week 3. The Bengals return home after playing an international game in Madrid last week, whereas the Steelers enjoy a rest advantage coming off their bye week. CBS Sports projects a 27-24 victory for Pittsburgh and recommends taking the Steelers at +3.5.
Carolina Panthers at New Orleans Saints
First place in the NFC South hangs in the balance as the Carolina Panthers visit the New Orleans Saints. Although quarterback Bryce Young holds a challenging 1-5 career record against this division rival, he showed encouraging signs in the loss to Denver by completing 71.7% of his passes and throwing three touchdowns. He now faces a vulnerable Saints secondary that allows 7.3 yards per attempt and a 99.5 passer rating. With New Orleans struggling at home with a 0-5 against-the-spread record this season, CBS Sports projects a 24-21 win for Carolina and picks the Panthers at +2.5.
Kansas City Chiefs at Atlanta Falcons
Like Cincinnati, the Atlanta Falcons return immediately following an international appearance in Madrid last week, putting them at a disadvantage against the Kansas City Chiefs. Patrick Mahomes comes into the matchup with five touchdowns over his last two games and newly acquired wide receiver Josh Downs to boost the passing game. The Falcons defense recently traded away star safety Jessie Bates III to the Jaguars and struggled against Cincinnati. CBS Sports projects a 26-20 win for Kansas City and sets the pick as the Chiefs at -3.
Jacksonville Jaguars at Tennessee Titans
The Jacksonville Jaguars aggressively bolstered their defense before the trade deadline by acquiring Jessie Bates III, Jordan Davis, and Davon Godchaux for a potential Super Bowl push. They face a Tennessee Titans squad that has parted ways with key defensive players like Amani Hooker and Jeffery Simmons. Trevor Lawrence enters Week 10 ranked second among qualified quarterbacks with a 111.7 passer rating, leading an elite Jacksonville defense that allows just 15.1 points per game. CBS Sports projects a 34-16 blowout and backs the Jaguars at -10.5.
Seattle Seahawks at Las Vegas Raiders
The Las Vegas Raiders turn to 2026 No. 1 overall pick Fernando Mendoza for his first career start following the trade of Kirk Cousins to Minnesota. Mendoza faces a daunting task against a Seattle Seahawks defense allowing a league-low 244.2 total yards per game. Meanwhile, the Raiders defense has allowed 30-plus points in six consecutive games, giving the Seahawks ample opportunity to score. CBS Sports projects a 30-20 victory for Seattle and selects the Seahawks at -6.5.
Additional Week 10 Matchups
CBS Sports provides projected scores and betting lines for the remaining slate of games. In international action in Munich, the Detroit Lions are projected to defeat the New England Patriots 30-20 with a -2.5 line. The Buffalo Bills are favored at -8.5 in a projected 33-21 win over the New York Jets, while the Cleveland Browns are picked at +4.5 in a tight 23-20 loss to the Houston Texans.
Elsewhere, the Indianapolis Colts are expected to beat the Miami Dolphins 27-17 with a -3.5 line, and the Minnesota Vikings are projected at +2.5 in a narrow 24-23 loss to the Green Bay Packers. The Los Angeles Rams are heavily favored at -9.5 in a 27-17 projection over the Arizona Cardinals, and the San Francisco 49ers are slated at -4.5 in a 33-24 win against the Dallas Cowboys. Closing out the week on Monday, the Baltimore Ravens are projected to defeat the Los Angeles Chargers 24-17 with a -4.5 line.
