Division leaders meet when the Buffalo Bills battle the Minnesota Vikings in a key matchup on Monday Night Football. Kickoff is scheduled for 8:15 p.m. ET from U.S. Bank Stadium in Minneapolis.
Matchup Preview and Odds
Buffalo enters the game coming off a 36-10 victory over Baltimore on November 1. The Bills hold a 6-1 record, lead the AFC East, and carry a 3-0 record on the road in 2026. Minnesota suffered its first loss of the season on the same day, falling 19-15 at Detroit. The Vikings also stand at 6-1, lead the NFC North, and are undefeated at 3-0 on their home field this year.
According to CBS Sports Headlines, the latest odds list Buffalo as a 3-point favorite, with the over/under for total points set at 43.5. The money line places the Bills at -175 and the Vikings at +145.
Model Predictions for Monday Night Football
A proven computer model that simulates every NFL game 10,000 times has revealed its top predictions for the contest. The model entered Week 9 on a 60-51 run on top-rated picks dating back to 2024 and is up more than $5,000 for $100 players since its inception.
Following its simulations, the model recommends going Over the 43.5-point total, a result that connects in 52% of simulations with a forecast of 45 combined points. The Over has hit in three of the last four Buffalo games and holds a 5-2 record for the Bills this season. Furthermore, three of the past four meetings between the teams in Minnesota have gone over the total.
The Over is 4-3 for the Vikings over their last seven games against AFC opponents. The model projects that Carson Wentz starting at quarterback will energize the Minnesota offense, with three Vikings expected to exceed 60 scrimmage yards. Meanwhile, Josh Allen and James Cook are projected to combine for nearly 125 rushing yards.
Aside from the over/under selection, the model has identified a side of the spread that hits in well over 50% of simulations.
